Executive Order Launching the Genesis Mission Active
Agency
Executive Office of the President
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Summary
The Genesis Mission Executive Order launches a national, DOE‑led initiative to build an integrated AI‑enabled science platform that uses federal data, supercomputing, and automated labs to accelerate research in high‑priority technology and security domains. It explicitly casts AI‑driven science as a Manhattan Project‑scale effort to enhance U.S. technological leadership, national security, and economic competitiveness.
The EO’s core purpose is to create a unified AI platform that connects federal scientific datasets, high‑performance computing, and advanced instruments so researchers can train scientific foundation models, run AI agents, and automate experiments to “solve the most challenging problems of this century.” It frames Genesis as a strategic bet on AI to revitalize U.S. science, placing AI at the center of long‑term competition over critical technologies and likening the effort to the urgency and ambition of the Manhattan Project.
The order formally establishes the Genesis Mission as a national effort and designates the Secretary of Energy as the lead, responsible for planning, integrating DOE resources, and potentially appointing a senior official to run day‑to‑day operations. DOE is directed to coordinate with other federal agencies, national laboratories, academia, and industry, using standardized partnership and IP frameworks while maintaining strict security, classification, privacy, and export‑control safeguards.
DOE must assemble a secure, unified infrastructure that ties together supercomputers, AI and quantum systems, cloud environments, large scientific datasets, domain‑specific foundation models, and robotic or automated laboratories. The EO calls for capabilities such as AI agents, synthetic data generation, secure multi‑tenant AI environments, and automated experimentation, with timelines to inventory compute and data resources and demonstrate an initial operating capability using existing infrastructure.